Description: Concepts in Biochemical Pharmacology Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Part 3 Author(s): P.S. Randall, James R. Gillette, J.R. Mitchell Format: Paperback Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN-13: 9783642463167, 978-3642463167 Synopsis Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
Price: 74.24 GBP
Location: Aldershot
End Time: 2025-01-28T09:00:10.000Z
Shipping Cost: 38.57 GBP
Product Images
Item Specifics
Return postage will be paid by: Buyer
Returns Accepted: Returns Accepted
After receiving the item, your buyer should cancel the purchase within: 60 days
Return policy details:
Book Title: Concepts in Biochemical Pharmacology
Number of Pages: 482 Pages
Publication Name: Concepts in Biochemical Pharmacology: Part 3
Language: English
Publisher: Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Item Height: 244 mm
Subject: Medicine, Pharmacy
Publication Year: 2012
Type: Textbook
Item Weight: 874 g
Author: James R. Gillette, J.R. Mitchell
Item Width: 170 mm
Series: Handbook of Experimental Pharmacology
Format: Paperback
